{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Hypothesis\n",
    "This notebook is used to read the data from the pickle files and to test the hypothesis that in the age group of 60-70 the frequency of a sinus bradycardia is significantly higher than in the other age groups.\n",
    "For that instance the chi-squared test is used."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "import pandas as pd\n",
    "import seaborn as sns\n",
    "import matplotlib.pyplot as plt\n",
    "import pickle\n",
    "import sys\n",
    "\n",
    "\n",
    "from scipy.stats import chi2_contingency\n",
    "sys.path.append('../scripts')\n",
    "import data_helper\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Reading GSVT\n"
     ]
    },
    {
     "ename": "FileNotFoundError",
     "evalue": "[Errno 2] No such file or directory: 'C:/Studium/dsa/data/GSVT.pkl'",
     "output_type": "error",
     "traceback": [
      "\u001b[1;31m---------------------------------------------------------------------------\u001b[0m",
      "\u001b[1;31mFileNotFoundError\u001b[0m                         Traceback (most recent call last)",
      "Cell \u001b[1;32mIn[3], line 1\u001b[0m\n\u001b[1;32m----> 1\u001b[0m data \u001b[38;5;241m=\u001b[39m \u001b[43mdata_helper\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mload_data\u001b[49m\u001b[43m(\u001b[49m\u001b[43monly_demographic\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[38;5;28;43;01mTrue\u001b[39;49;00m\u001b[43m)\u001b[49m\n\u001b[0;32m      3\u001b[0m \u001b[38;5;28mprint\u001b[39m(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mNumber of patients per category:\u001b[39m\u001b[38;5;124m\"\u001b[39m)\n\u001b[0;32m      4\u001b[0m \u001b[38;5;28;01mfor\u001b[39;00m cat_name \u001b[38;5;129;01min\u001b[39;00m data\u001b[38;5;241m.\u001b[39mkeys():\n",
      "File \u001b[1;32mc:\\Users\\klara\\projects\\DSA\\DSA_SS24\\notebooks\\../scripts\\data_helper.py:37\u001b[0m, in \u001b[0;36mload_data\u001b[1;34m(only_demographic, path_settings)\u001b[0m\n\u001b[0;32m     35\u001b[0m \u001b[38;5;28;01mfor\u001b[39;00m cat_name \u001b[38;5;129;01min\u001b[39;00m labels\u001b[38;5;241m.\u001b[39mkeys():\n\u001b[0;32m     36\u001b[0m     \u001b[38;5;28mprint\u001b[39m(\u001b[38;5;124mf\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mReading \u001b[39m\u001b[38;5;132;01m{\u001b[39;00mcat_name\u001b[38;5;132;01m}\u001b[39;00m\u001b[38;5;124m\"\u001b[39m)\n\u001b[1;32m---> 37\u001b[0m     \u001b[38;5;28;01mwith\u001b[39;00m \u001b[38;5;28;43mopen\u001b[39;49m\u001b[43m(\u001b[49m\u001b[38;5;124;43mf\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[38;5;132;43;01m{\u001b[39;49;00m\u001b[43mpath_data\u001b[49m\u001b[38;5;132;43;01m}\u001b[39;49;00m\u001b[38;5;124;43m/\u001b[39;49m\u001b[38;5;132;43;01m{\u001b[39;49;00m\u001b[43mcat_name\u001b[49m\u001b[38;5;132;43;01m}\u001b[39;49;00m\u001b[38;5;124;43m.pkl\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[38;5;124;43mrb\u001b[39;49m\u001b[38;5;124;43m'\u001b[39;49m\u001b[43m)\u001b[49m \u001b[38;5;28;01mas\u001b[39;00m f:\n\u001b[0;32m     38\u001b[0m         records \u001b[38;5;241m=\u001b[39m pickle\u001b[38;5;241m.\u001b[39mload(f)\n\u001b[0;32m     39\u001b[0m         \u001b[38;5;28;01mif\u001b[39;00m only_demographic:\n",
      "\u001b[1;31mFileNotFoundError\u001b[0m: [Errno 2] No such file or directory: 'C:/Studium/dsa/data/GSVT.pkl'"
     ]
    }
   ],
   "source": [
    "data = data_helper.load_data(only_demographic=True)\n",
    "\n",
    "print(\"Number of patients per category:\")\n",
    "for cat_name in data.keys():\n",
    "    print(f\"{cat_name}: {len(data[cat_name])}\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [
    {
     "ename": "NameError",
     "evalue": "name 'data_helper' is not defined",
     "output_type": "error",
     "traceback": [
      "\u001b[1;31m---------------------------------------------------------------------------\u001b[0m",
      "\u001b[1;31mNameError\u001b[0m                                 Traceback (most recent call last)",
      "Cell \u001b[1;32mIn[1], line 1\u001b[0m\n\u001b[1;32m----> 1\u001b[0m data_org \u001b[38;5;241m=\u001b[39m \u001b[43mdata_helper\u001b[49m\u001b[38;5;241m.\u001b[39mload_data(only_demographic\u001b[38;5;241m=\u001b[39m\u001b[38;5;28;01mTrue\u001b[39;00m)\n\u001b[0;32m      3\u001b[0m df_dgc \u001b[38;5;241m=\u001b[39m pd\u001b[38;5;241m.\u001b[39mDataFrame(data_org)\n",
      "\u001b[1;31mNameError\u001b[0m: name 'data_helper' is not defined"
     ]
    }
   ],
   "source": [
    "data_org = data_helper.load_data(only_demographic=True)\n",
    "\n",
    "df_dgc = pd.DataFrame(data_org)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "metadata": {},
   "outputs": [
    {
     "ename": "NameError",
     "evalue": "name 'df_dgc' is not defined",
     "output_type": "error",
     "traceback": [
      "\u001b[1;31m---------------------------------------------------------------------------\u001b[0m",
      "\u001b[1;31mNameError\u001b[0m                                 Traceback (most recent call last)",
      "Cell \u001b[1;32mIn[21], line 36\u001b[0m\n\u001b[0;32m      1\u001b[0m \u001b[38;5;66;03m# #path = \"C:/Studium/dsa/data\"\u001b[39;00m\n\u001b[0;32m      2\u001b[0m \u001b[38;5;66;03m# #path = \"C:/Users/Nils/Documents/HS-Mannheim/0000_MASTER/DSA/EKG_Prog/data\"\u001b[39;00m\n\u001b[0;32m      3\u001b[0m \u001b[38;5;66;03m# path = \"C:/Users/klara/projects/DSA/data\"\u001b[39;00m\n\u001b[1;32m   (...)\u001b[0m\n\u001b[0;32m     33\u001b[0m \n\u001b[0;32m     34\u001b[0m \u001b[38;5;66;03m# Change from group to category\u001b[39;00m\n\u001b[0;32m     35\u001b[0m age_categories \u001b[38;5;241m=\u001b[39m [\u001b[38;5;241m0\u001b[39m, \u001b[38;5;241m10\u001b[39m, \u001b[38;5;241m20\u001b[39m, \u001b[38;5;241m30\u001b[39m, \u001b[38;5;241m40\u001b[39m, \u001b[38;5;241m50\u001b[39m, \u001b[38;5;241m60\u001b[39m, \u001b[38;5;241m70\u001b[39m, \u001b[38;5;241m80\u001b[39m, \u001b[38;5;241m90\u001b[39m]\n\u001b[1;32m---> 36\u001b[0m df_dgc[\u001b[38;5;124m'\u001b[39m\u001b[38;5;124mage_group\u001b[39m\u001b[38;5;124m'\u001b[39m] \u001b[38;5;241m=\u001b[39m pd\u001b[38;5;241m.\u001b[39mcut(\u001b[43mdf_dgc\u001b[49m[\u001b[38;5;124m'\u001b[39m\u001b[38;5;124mage\u001b[39m\u001b[38;5;124m'\u001b[39m], bins\u001b[38;5;241m=\u001b[39mage_categories)\n\u001b[0;32m     37\u001b[0m corr_matrix_age_diag\u001b[38;5;241m=\u001b[39m pd\u001b[38;5;241m.\u001b[39mcrosstab(df_dgc[\u001b[38;5;124m'\u001b[39m\u001b[38;5;124mage_group\u001b[39m\u001b[38;5;124m'\u001b[39m], df_dgc[\u001b[38;5;124m'\u001b[39m\u001b[38;5;124mdiag\u001b[39m\u001b[38;5;124m'\u001b[39m])\n\u001b[0;32m     39\u001b[0m \u001b[38;5;66;03m# Chi-square test\u001b[39;00m\n",
      "\u001b[1;31mNameError\u001b[0m: name 'df_dgc' is not defined"
     ]
    }
   ],
   "source": [
    "# #path = \"C:/Studium/dsa/data\"\n",
    "# #path = \"C:/Users/Nils/Documents/HS-Mannheim/0000_MASTER/DSA/EKG_Prog/data\"\n",
    "# path = \"C:/Users/klara/projects/DSA/data\"\n",
    "\n",
    "# categories_dict = {\n",
    "# 'SB':    [426177001],\n",
    "# 'AFIB':  [164889003, 164890007],\n",
    "# 'GSVT':  [426761007, 713422000, 233896004, 233897008, 713422000],\n",
    "# 'SR':    [426783006, 427393009]\n",
    "# }\n",
    "\n",
    "# data = {}\n",
    "# for cat_name in categories_dict.keys():\n",
    "#     print(f\"Reading {cat_name}\")\n",
    "#     with open(f'{path}/{cat_name}.pkl', 'rb') as f:\n",
    "#         records = pickle.load(f)\n",
    "#         data[cat_name] = records\n",
    "#         print(f\"Length of {cat_name}: {len(records)}\")\n",
    "\n",
    "# data_demographic = {'age':[], 'diag':[], 'gender':[]}\n",
    "# for cat_name, records in data.items():\n",
    "#     for record in records:\n",
    "#         age = record.comments[0].split(' ')[1]\n",
    "#         sex = record.comments[1].split(' ')[1]\n",
    "#         if age == 'NaN' or sex == 'NaN':\n",
    "#             continue\n",
    "#         # cut Age: from alter string \n",
    "#         data_demographic['age'].append(int(age))\n",
    "#         data_demographic['diag'].append(cat_name)\n",
    "#         data_demographic['gender'].append(sex)\n",
    "\n",
    "# df_dgc = pd.DataFrame(data_demographic)\n",
    "\n",
    "# Change from group to category\n",
    "age_categories = [0, 10, 20, 30, 40, 50, 60, 70, 80, 90]\n",
    "df_dgc['age_group'] = pd.cut(df_dgc['age'], bins=age_categories)\n",
    "corr_matrix_age_diag= pd.crosstab(df_dgc['age_group'], df_dgc['diag'])\n",
    "\n",
    "# Chi-square test\n",
    "chi2, p, _, _ = chi2_contingency(corr_matrix_age_diag)\n",
    "\n",
    "# Difference between observed and expected frequencies\n",
    "print(f\"Chi-Square Statistic: {chi2}\")\n",
    "print(f\"P-value: {p}\")\n",
    "\n",
    "# Check if SB (Sinusbradykardie) has a significantly higher frequency in the 60-70 age group\n",
    "sb_60_70 = corr_matrix_age_diag.loc[pd.Interval(60, 70, closed='right'), 'SB']\n",
    "sb_other = corr_matrix_age_diag.drop(pd.Interval(60, 70, closed='right')).sum()['SB']\n",
    "total_60_70 = corr_matrix_age_diag.loc[pd.Interval(60, 70, closed='right')].sum()\n",
    "total_other = corr_matrix_age_diag.drop(pd.Interval(60, 70, closed='right')).sum().sum()\n",
    "\n",
    "# Frequency table for the specific Chi-Square test\n",
    "observed = [[sb_60_70, total_60_70 - sb_60_70], [sb_other, total_other - sb_other]]\n",
    "chi2_sb, p_sb = chi2_contingency(observed)[:2]\n",
    "\n",
    "\n",
    "print(f\"Chi-Square Statistic for SB in 60-70 vs others: {chi2_sb}\")\n",
    "print(f\"P-value for SB in 60-70 vs others: {p_sb}\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "The results can be interpreted as followed:\n",
    "\n",
    "- The first value returned is the Chi-Square Statistic that shows the difference between the observed and the expected frequencies. Here, a bigger number indicates a bigger difference. The p-value shows the probability of this difference being statistically significant. If the p-value is below the significance level of 0.05, the difference is significant.\n",
    "\n",
    "- The Chi-Square Statistic for sinus bradycardia in the age group 60-70 compared to the other age groups, is a value that shows whether there is a significant difference in the frequency of sinus bradycardia in the age group 60-70 in comparison to the other age groups. If the p-value is smaller than the significance level of 0.05, the difference in the frequency between the age group 60-70 and the other age groups is significant."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  }
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