{
 "cells": [
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   "source": [
    "# Hypothesis\n",
    "This notebook is used to read the data from the pickle files and to test the hypothesis that in the age group of 60-70 the frequency of a sinus bradycardia is significantly higher than in the other age groups.\n",
    "For that instance the chi-squared test is used."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [],
   "source": [
    "import pandas as pd\n",
    "import seaborn as sns\n",
    "import matplotlib.pyplot as plt\n",
    "import pickle\n",
    "from scipy.stats import chi2_contingency\n",
    "from data_helper import *\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Reading SB\n",
      "Length of SB: 50\n",
      "Reading AFIB\n",
      "Length of AFIB: 27\n",
      "Reading GSVT\n",
      "Length of GSVT: 0\n",
      "Reading SR\n",
      "Length of SR: 13\n",
      "Chi-Square Statistic: 38.266574797751275\n",
      "P-value: 0.0004730210823940083\n",
      "Chi-Square Statistic for SB in 60-70 vs others: 1.4858035714285718\n",
      "P-value for SB in 60-70 vs others: 0.22286870264719977\n"
     ]
    }
   ],
   "source": [
    "#path = \"C:/Studium/dsa/data\"\n",
    "#path = \"C:/Users/Nils/Documents/HS-Mannheim/0000_MASTER/DSA/EKG_Prog/data\"\n",
    "path = \"C:/Users/klara/projects/DSA/data\"\n",
    "\n",
    "categories_dict = {\n",
    "'SB':    [426177001],\n",
    "'AFIB':  [164889003, 164890007],\n",
    "'GSVT':  [426761007, 713422000, 233896004, 233897008, 713422000],\n",
    "'SR':    [426783006, 427393009]\n",
    "}\n",
    "\n",
    "data = {}\n",
    "for cat_name in categories_dict.keys():\n",
    "    print(f\"Reading {cat_name}\")\n",
    "    with open(f'{path}/{cat_name}.pkl', 'rb') as f:\n",
    "        records = pickle.load(f)\n",
    "        data[cat_name] = records\n",
    "        print(f\"Length of {cat_name}: {len(records)}\")\n",
    "\n",
    "data_demographic = {'age':[], 'diag':[], 'gender':[]}\n",
    "for cat_name, records in data.items():\n",
    "    for record in records:\n",
    "        age = record.comments[0].split(' ')[1]\n",
    "        sex = record.comments[1].split(' ')[1]\n",
    "        if age == 'NaN' or sex == 'NaN':\n",
    "            continue\n",
    "        # cut Age: from alter string \n",
    "        data_demographic['age'].append(int(age))\n",
    "        data_demographic['diag'].append(cat_name)\n",
    "        data_demographic['gender'].append(sex)\n",
    "\n",
    "df_dgc = pd.DataFrame(data_demographic)\n",
    "\n",
    "# Change from group to category\n",
    "age_categories = [0, 10, 20, 30, 40, 50, 60, 70, 80, 90]\n",
    "df_dgc['age_group'] = pd.cut(df_dgc['age'], bins=age_categories)\n",
    "corr_matrix_age_diag= pd.crosstab(df_dgc['age_group'], df_dgc['diag'])\n",
    "\n",
    "# Chi-square test\n",
    "chi2, p, _, _ = chi2_contingency(corr_matrix_age_diag)\n",
    "\n",
    "# Difference between observed and expected frequencies\n",
    "print(f\"Chi-Square Statistic: {chi2}\")\n",
    "print(f\"P-value: {p}\")\n",
    "\n",
    "# Check if SB (Sinusbradykardie) has a significantly higher frequency in the 60-70 age group\n",
    "sb_60_70 = corr_matrix_age_diag.loc[pd.Interval(60, 70, closed='right'), 'SB']\n",
    "sb_other = corr_matrix_age_diag.drop(pd.Interval(60, 70, closed='right')).sum()['SB']\n",
    "total_60_70 = corr_matrix_age_diag.loc[pd.Interval(60, 70, closed='right')].sum()\n",
    "total_other = corr_matrix_age_diag.drop(pd.Interval(60, 70, closed='right')).sum().sum()\n",
    "\n",
    "# Frequency table for the specific Chi-Square test\n",
    "observed = [[sb_60_70, total_60_70 - sb_60_70], [sb_other, total_other - sb_other]]\n",
    "chi2_sb, p_sb = chi2_contingency(observed)[:2]\n",
    "\n",
    "\n",
    "print(f\"Chi-Square Statistic for SB in 60-70 vs others: {chi2_sb}\")\n",
    "print(f\"P-value for SB in 60-70 vs others: {p_sb}\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "The results can be interpreted as followed:\n",
    "\n",
    "- The first value returned is the Chi-Square Statistic that shows the difference between the observed and the expected frequencies. Here, a bigger number indicates a bigger difference. The p-value shows the probability of this difference being statistically significant. If the p-value is below the significance level of 0.05, the difference is significant.\n",
    "\n",
    "- The Chi-Square Statistic for sinus bradycardia in the age group 60-70 compared to the other age groups, is a value that shows whether there is a significant difference in the frequency of sinus bradycardia in the age group 60-70 in comparison to the other age groups. If the p-value is smaller than the significance level of 0.05, the difference in the frequency between the age group 60-70 and the other age groups is significant."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  }
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